Haldane's rule relating to hybrids of species and extended to speciation in evolutionary theory is easily stated: It was originally formulated in 1922 by the British evolutionary biologist J. B. S. Haldane. It is sometimes referred to as Haldane's law. In many organisms, such as mammals or Drosophila flies, males are the heterogametic sex, in that they have XY sex chromosomes, whereas females are homogametic, with XX chromosomes. However, in some other animals (i.e.